Tag Archives: Murine research models

Too exciting! Nobel Prize awarded for research on stuff that I’ve been writing about here

Visual recognition of places or scenes, mental navigation, a sense of place and the normal mental memory function that is the basis for the “method of loci” memory technique are some of the interesting psychological subjects that I have written about here, and it appears that my interests very much overlap with the areas of research pioneered by John O’Keefe and May-Britt and Edvard Moser, all winners of the 2014 Nobel Prize for Medicine. This team spent a great part of their careers doing research on rats, and their discoveries include grid cells and “place cells” which are nerve cells in the hippocampus that only activate when the rat is in a specific physical location. I’m not clear whether the grid cells and the place cells are the same thing or not. Read about their fascinating and important research here.

I’m feeling very frustrated right now as I am sure that somewhere in this blog I’ve written a description of an experience that I occasionally have while travelling in a train in unfamiliar lines or at night, in which it appears that two different mental navigational systems in my brain go “out of sync” causing a temporary sense of confusion about where I am. One of these navigational systems is based on visual perception of scenes while the other is based on a body-centred, visceral, embodied, spatial, sense of direction, and the common language “spoken” between these two systems is the visual memory of scenes, (which is of interest in my case because this function is encoded in pretty-much the same part of the brain as face memory, and I’m a super-recognizer). Normally the visual perception of scenes system informs and regularly updates the directional sense system, and the directional system accesses a sequentially-encoded system of visual memories of places and then sends predictions about expected scenery back to the visual system. Sometimes when visual scene recognition operates at the edges of ability and fails to provide input to or misinforms the directional system, the directional system works in an uncertain and speculative way, and at times is confronted with input of visual scenes that do not fit the predictions of expected scenery sent from the scene memory bank. This is the “spin-out” moment. Following this head-spinning moment of confusion is a sense of “Where the f*** are we?”, and my sense of navigation will either be reset from a combination of conscious knowledge of direction combined with visual memories of scenes or fresh comprehensible visual input. This is my interpretation of these types of experiences, which I believe are interesting and can inform us about normal mental navigation. I am very conscious of visual memories of scenes because I experience a number of types of synaesthesia in which these memories are either inducers or concurrents. I believe I am the first person in the world who has taken the time to write and publish full descriptions of these experiences, here at this blog. I have asserted that one of these types of synaesthesia is the same or very similar to the very powerful and ancient method of loci memory technique, which involves activation of a number of parts of the human brain, including the hippocampus.

Action-packed YouTube video clip

Immune cell in the brain swallows synapses to sculpt neurons during development.

Posted by NIHNINDS (National Institute of Neurological Disorders and Stroke) at YouTube on May 22, 2012.


The green thing is a mouse’s microglial cell. The movie is “courtesy Dorothy Schafer, Ph.D. and Beth Stevens, Ph.D. at Boston Children’s Hospital.” At this blog I have speculated that the kind of process shown in this brief video clip possibly happens less often in the brains of some people because they have lower levels of some of the complement chemicals that are a part of the immune system, with the result being the development of, or the retaining of, childhood or developmental synaesthesia. Some of the complement chemicals mark out synapses for destruction, I believe.